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We can now add the rs1801222 A allele as an additional risk factor

No adverse effects were observed on reproductive parameters when male dogs received 10 consecutive daily treatments of 15 mg/kg/day at 3 intervals (90, 45 and 14 days) prior to breeding or when female dogs received 10 consecutive daily treatments of 15 mg/kg/day at 4 intervals: between 30 and 0 days prior to breeding, early pregnancy (between 10th & 30th days), late pregnancy (between 40th & 60th days), and during lactation (the first 28 days)

Published 2013 Sep 30

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These findings provide further support for our proposal that replication stress induced by oncogenes such as HRASV12 or cyclin E1 is caused by R-loop-mediated TRCs